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Literature summary extracted from

  • Delage, E.; Ruelland, E.; Guillas, I.; Zachowski, A.; Puyaubert, J.
    Arabidopsis type-III phosphatidylinositol 4-kinases beta1 and beta2 are upstream of the phospholipase C pathway triggered by cold exposure (2012), Plant Cell Physiol., 53, 565-576.
    View publication on PubMed

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mg2+ required Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Arabidopsis thaliana
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Arabidopsis thaliana
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 cell suspension culture
-
 Arabidopsis thaliana
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Arabidopsis thaliana ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.67 AtPI4KIIIalpha1
-
 Arabidopsis thaliana
2.7.1.67 AtPI4KIIIbeta1
-
 Arabidopsis thaliana
2.7.1.67 AtPI4KIIIbeta2
-
 Arabidopsis thaliana
2.7.1.67 phosphatidylinositol 4-kinase
-
 Arabidopsis thaliana
2.7.1.67 PI4K
-
 Arabidopsis thaliana
2.7.1.67 type-II PI4K
-
 Arabidopsis thaliana
2.7.1.67 type-III phosphatidylinositol 4-kinase beta1
-
 Arabidopsis thaliana
2.7.1.67 type-III phosphatidylinositol 4-kinase beta2
-
 Arabidopsis thaliana
2.7.1.67 type-III PI4K
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.67 ATP
-
 Arabidopsis thaliana

General Information

EC Number General Information Comment Organism
2.7.1.67 malfunction phosphatidic acid resulting from the phosphoinositide-dependent phospholipase C pathway is significantly lowered in a pi4kIIIbeta1beta2 double mutant exposed to cold stress, phenotype, overview. The root growth in the double mutant is 5fold reduced at 12°C Arabidopsis thaliana
2.7.1.67 metabolism the enzyme catalyzes the first step in generating the phosphoinositides hydrolyzed by phosphoinositide-dependent phospholipase C, EC 3.1.4.11, that produces diacylglycerol which can be phosphorylated to phosphatidic acid. Type-III PIK activity is upstream of the phosphoinositide-dependent phospholipase C activity Arabidopsis thaliana
2.7.1.67 physiological function Arabidopsis thaliana type-III phosphatidylinositol 4-kinases beta1 and beta2 are upstream of the phospholipase C pathway triggered by cold exposure, overview. De novo synthesis of 1-phosphatidyl-1D-myo-inositol 4-phosphate by PI4Ks occurs in parallel to phosphoinositide-dependent phospholipase C activation Arabidopsis thaliana